Superficial angiomyxoma of penis: a case report of a 6-year follow-up

tumor cells were diffusely positive for vimentin, CD34, and CD44, but negative for smooth muscle actin, desmin, S-100 protein, and pan-keratins (Figure 4). Clinical and pathological findings contributed to the diagnosis of penial superficial angiomyxoma. The margins of the sections were free from tumor cells. An 80-month follow-up showed no sign of SAM recurrence, and the enlargement of bilateral inguinal lymph nodes disappeared 8 months after complete resection of the tumors. Superficial angiomyxoma is a rare, benign cutaneous tumor, which was first described in 1988 by Allen et al. 3 Superficial angiomyxoma has a tendency for local recurrence after incomplete excision, but lacks metastatic potential. 3,4 The tumor usually presents as a nodular lesion on the trunk, head, neck, and even female genital region such as vulva. There have been only six reported cases of superficial angiomyxoma on the scrotum. and rarely occurs in the genital region in males. In this unique case, an 18-year-old male, was referred to our hospital because of recurring masses on his penis. His clinical, histopathological, and immunohistochemical findings showed a polypoid tumor without invasive growth, and no apparent atypism in the tumor cells. Based on the above factors, aggressive angiomyxoma and other malignant tumors were ruled out. The regression of enlarged inguinal lymph nodes after tumor resection demonstrated its benign feature. Neurogenic tumors such as dermal nerve sheath myxoma and myxoid neurofibroma were unlikely, since none of the tumor cells expressed S-100 protein. 6 Superficial angiomyxomas are generally immunoreactive with vimentin and CD34, 2 which was consistent with the present case. In addition, neutrophilic infiltration in superficial angiomyxoma distinguishes it from other myxoid lesions, and is an important histological clue for the differential diagnosis. 4,6 Complete surgical excision is very crucial for superficial angiomyxomas because of its high rate of local recurrence between 20% and 40%. In this letter, we describe a complete surgical excision and long-term follow-up of penial superficial angiomyxomas. In the present case, no recurrence was observed during a 6-year follow-up, due to complete surgical excision. Though superficial angiomyxomas have a good overall prognosis, without invasion of deeper structures, 2,7,9 the patients should be followed up for long-term. AUTHOR CONTRIBUTIONS YCW and GPZ carried out the surgery and follow-up; YCW and ZX drafted the manuscript; XML carried out histopathological analysis and immunohistochemical testing; ZPW participated in the design Dear Editor, We report a case of an 18-year-old Chinese man with two …